Article No
AG-CN2-0430-C100
CAS No | 121263-19-2 |
MW | 790.8 |
Article No | AG-CN2-0430-C100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Description | Calphostin C |
Supplier | Adipogen Life Sciences |
Format | Powder |
Notes | Chemical. CAS: 121263-19-2. Formula: C44H38O14. MW: 790.8. Isolated from Cladosporium cladosporioides sp. Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion|Potent and highly specific cell permeable protein kinase C (PKC) inhibitor [1]. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion |
Molecular Formula | C44H38O14 |
Alias Names | UCN 1028C; PKF115-584; Cal-C |
Product Type | Chemicals & Biochemicals |
Purity | >95% |
Research Area | Cell Death |
Shipping Information | RT |
Size | 100 ug |
Solubility | Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in water. |
Stability | Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
Storage | -20°C, 4°C |
Technical Specifications | Chemical. CAS: 121263-19-2. Formula: C44H38O14. MW: 790.8. Isolated from Cladosporium cladosporioides sp. Potent and highly specific cell permeable protein kinase C (PKC) inhibitor. The inhibition of PKC is light-dependent. PKA, PKG, DAG kinase, phospholipase D1 and D2, myosin light chain kinase and c-Src inhibitor. Anticancer compound. Inhibits cell proliferation and strongly induces apoptosis in vitro. Inducer of endoplasmic reticulum ER-stress. Shown to directly and potently block L-type Ca channels. Calphostin C specifically inhibits contraction-stimulated glucose transport but not insulin-stimulated glucose transport in skeletal muscle. Wnt/beta-catenin/lef-1 signaling inhibitor. beta-catenin/TCF antagonist. Inhibits Wnt-activated genes in a dose-dependent fashion |
Product Page Updated | 2024-02-01T08:25:01.492Z |