(+)-Catechin . hydrate

Article No AG-CN2-0407-M500
Product Type Chemicals & Biochemicals
Research Area Metabolism
Format Powder
Size 500 mg

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Specifications

CAS No 225937-10-0 and 88191-48-4
MW 290.3 . 18.0
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/11815
Description (+)-Catechin . hydrate
Supplier Adipogen Life Sciences
Notes Chemical. CAS: 225937-10-0 or 88191-48-4. Formula: C15H14O6 . H2O. MW: 290.3 . 18.0. Isolated from Uncaria rhynchophylla. Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic.
Molecular Formula C15H14O6 . H2O
Alias Names Cianidanol; Cyanidol; Catechol; Catechuic acid; NSC 2819; (+)-3,3',4',5,7-Flavanpentol
Purity >95% (NMR)
References Histamine and acute haemorrhagic lesions in rat gastric mucosa: prevention of stress ulcer formation by (+)-catechin, an inhibitor of specific histidine decarboxylase in vitro: H.J. Reimann, et al.; Agents Actions 7, 69 (1977) | Flavan-3-ols isolated from some medicinal plants inhibiting COX-1 and COX-2 catalysed prostaglandin biosynthesis: Y. Noreen, et al.; Planta Med. 64, 520 (1998) | (+)-Catechin as antioxidant: mechanisms preventing human plasma oxidation and activity in red wines: S.B. Lotito & C.G. Fraga; Biofactors 10, 125 (1999) | Flavonoids as anticancer agents: structure-activity relationship study: M. Lopez-Lazaro; Curr. Med. Chem. Anticancer Agents 2, 691 (2002) (Review) | Effects of (+)-catechin on the function of osteoblastic cells: E.M. Choi & J.K. Hwang; Biol. Pharm. Bull. 26, 523 (2003) | Dietary supplementation of (+)-catechin protects against UVB-induced skin damage by modulating antioxidant enzyme activities: S.E. Jeon, et al.; Photodermatol. Photoimmunol. Photomed. 19, 235 (2003) | Phytotoxic and antimicrobial activities of catechin derivatives: R. Veluri, et al.; J. Agric. Food Chem. 52, 1077 (2004) | Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseases: S. Mandel & M.B. Youdim; Free Radic. Biol. Med. 37, 304 (2004) (Review) | A green tea component, catechin, rapidly induces apoptosis of myeloid leukemic cells via modulation of reactive oxygen species production in vitro and inhibits tumor growth in vivo: L. Gordon; Haematologica 90, 290 (2005) | (+)-Catechin, an ingredient of green tea, protects murine microglia from oxidative stress-induced DNA damage and cell cycle arrest: Q. Huang, et al.; J. Pharmacol. Sci. 98, 16 (2005) | Monoamine oxidase B (MAO-B) inhibition by active principles from Uncaria rhynchophylla: W.C. Hou; J. Ethnopharmacol. 100, 216 (2005) | (+)-Catechin prevents ultraviolet B-induced human keratinocyte death via inhibition of JNK phosphorylation: W.B. Wu, et al.; Life Sci. 79, 801 (2006) | Antispasmodic, bronchodilator and vasodilator activities of (+)-catechin, a naturally occurring flavonoid: M.N. Ghayur, et al.; Arch. Pharm. Res. 30, 970 (2007) | (+)-Catechin inhibits tumour angiogenesis and regulates the production of nitric oxide and TNF-alpha in LPS-stimulated macrophages: C. Guruvayoorappan & G. Kuttan; Innate Immun. 14, 160 (2008) | Insulin mimetic impact of Catechin isolated from Cassia fistula on the glucose oxidation and molecular mechanisms of glucose uptake on Streptozotocin-induced diabetic Wistar rats: P. Daisy, et al.; Phytomedicine 17, 28 (2010) | Catechin hydrate suppresses MCF-7 proliferation through TP53/Caspase-mediated apoptosis: A.A. Alshatwi; J. Exp. Clin. Cancer Res. 29, 167 (2010) | Catechin hydrate inhibits proliferation and mediates apoptosis of SiHa human cervical cancer cells: A.A. Al-Hazzani & A.A. Alshatwi; Food Chem. Toxicol. 49, 3281 (2011)
Solubility Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Source / Host plant
Storage -20°C
Technical Specifications Specific histidine decarboxylase inhibitor. Anti-inflammatory. COX-1 inhibitor. Antioxidant flavonoid. Free radical scavenger. Inhibits lipid peroxidation. Antimetastatic and anticancer compound. Antiangiogenic. Anti-osteoporotic. Antibacterial and antifungal. Neuroprotective. Mono oxidase B inhibitor. Apoptosis and cell cycle arrest inducer. JNK phosphorylation inhibitor. Antispasmodic. Insulin-mimetic.

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