Chemicals & Biochemicals

Asiatic acid

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Asiatic acid

Article No

AG-CN2-0400-M005

Size

5 mg

Source / Host

plant

Shipping Information

Ambient

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Specifications

CAS No 464-92-6
MW 488.7
Article No AG-CN2-0400-M005
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Description Asiatic acid
Supplier Adipogen Life Sciences
Format Powder
Notes Apoptosis inducer. Cell cycle arrest inducer. Anticancer compound Antioxidant. Hepatoprotective. Inhibits TGF-beta/Smad-mediated fibrogenesis. Stimulates wound healing. Anti-diabetic. Glycogen phosphorylase inhibitor. Neuroprotective. Modulates multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Down regulates BACE1 and increases ADAM10 maturation. Anti-hyperglycemic compound. Anti-inflammatory and antinociceptive compound. Antiangiogenic. Acetylcholinesterase (AChE) inhibitor. PPARgamma inhibitor through a C/EBPbeta-independent mechanisms. Anti-osteoporotic. Inhibits adipogenic differentiation of bone marrow stromal cells (BMSC).
Molecular Formula C30H48O5
Alias Names 2alpha,23-Dihydroxyursolic acid; Dammarolic acid; NSC166063
Product Type Chemicals & Biochemicals
Purity >95% (NMR)
References Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells: Y.L. Hsu, et al.; J. Pharmacol. Exp. Ther. 313, 333 (2005) | Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice: J. Gao, et al.; J. Pharm. Pharmacol. 58, 227 (2006) | Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid: G.M. Gurfinkel, et al.; Apoptosis 11, 1463 (2006) | Structure-activity relationship study of asiatic acid derivatives for new wound healing agent: B.S. Jeong; Arch. Pharm. Res. 29, 556 (2006) | Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade: X.L. Tang, et al.; Biol. Pharm. Bull. 32, 1399 (2009) | Synthesis and biological evaluation of asiatic acid derivatives as inhibitors of glycogen phosphorylases: L. Zhang, et al.; Chem. Biodivers. 6, 864 (2009) | Withanolide A and asiatic acid modulate multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance: S.P. Patil, et al.; J. Nat. Prod. 73, 1196 (2010) | Asiatic acid preserves beta cell mass and mitigates hyperglycemia in streptozocin-induced diabetic rats: J. Liu, et al.; Diabetes Metab. Res. Rev. 26, 448 (2010) | Antinociceptive activities and the mechanisms of anti-inflammation of asiatic Acid in mice: S.S. Huang, et al.; Evid. Based Complement Alternat. Med. 2011, 895857 (2011) | Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models: C.V. Kavitha, et al.; PLoS One 6, e22745 (2011) | Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity: M.N. Nasir, et al.; Phytomedicine 19, 311 (2012) | Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro: L.X. Tang, et al.; PLoS One 7, e31350 (2012) | Asiatic acid attenuates infarct volume, mitochondrial dysfunction, and matrix metalloproteinase-9 induction after focal cerebral ischemia: K.Y. Lee, et al.; Stroke 43, 1632 (2012) | Efficacy of asiatic acid, a pentacyclic triterpene on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-induced diabetic rats: V. Ramachandran & R. Saravanan; Phytomedicine 20, 230 (2013) | Asiatic Acid Inhibits Adipogenic Differentiation of Bone Marrow Stromal Cells: Z.W. Li, et al.; Cell Biochem. Biophys. 68, 437 (2014)
Research Area Metabolism
Shipping Information Ambient
Size 5 mg
Solubility Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Source / Host plant
Stability Stable for at least 2 years after receipt when stored at -20°C.
Storage -20°C
Technical Specifications Chemical. CAS: 464-92-6. Formula: C30H48O5. MW: 488.7. Isolated from Centella asiatica. Apoptosis inducer. Cell cycle arrest inducer. Anticancer compound Antioxidant. Hepatoprotective. Inhibits TGF-beta/Smad-mediated fibrogenesis. Stimulates wound healing. Anti-diabetic. Glycogen phosphorylase inhibitor. Neuroprotective. Modulates multiple targets associated with amyloid-beta precursor protein processing and amyloid-beta protein clearance. Down regulates BACE1 and increases ADAM10 maturation. Anti-hyperglycemic compound. Anti-inflammatory and antinociceptive compound. Antiangiogenic. Acetylcholinesterase (AChE) inhibitor. PPARgamma inhibitor through a C/EBPbeta-independent mechanisms. Anti-osteoporotic. Inhibits adipogenic differentiation of bone marrow stromal cells (BMSC).
Product Page Updated 2019-07-12T09:17:06.689Z

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