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Altenusin

Chemicals & Biochemicals

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Article No

AG-CN2-0143-M001

Size

1 mg

Shipping Information

Article No

AG-CN2-0143-M001

Size

1 mg

Specifications

CAS No	31186-12-6
MW	290.3
Article No	AG-CN2-0143-M001
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Altenusin
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Antibiotic [7]. Antifungal penicillide [8]. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor [2]. Strong pp60c-Src inhibitor [3]. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases [3]. Myosin light chain kinase inhibitor [1]. Exhibits anti-HIV-1 integrase activity [4]. Cytotoxic activity against mouse lymphoma cells [6]. Anti-protozoan, trypanothione reductase (TR) inhibitor [5]. Phytotoxin [9].\|Chemical. CAS: 31186-12-6. Formula: C15H14O6. MW: 290.3. Isolated from Penicillium sp. Antibiotic. Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor. Strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity. Cytotoxic activity against mouse lymphoma cells. Anti-protozoan, trypanothione reductase (TR) inhibitor. Phytotoxin.
Molecular Formula	C15H14O6
Alias Names	MS 341
Product Type	Chemicals & Biochemicals
Purity	>97%
Research area	Metabolism
Shipping Information	RT
Size	1 mg
Solubility	Soluble in methanol, ethanol or DMSO.
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 31186-12-6. Formula: C15H14O6. MW: 290.3. Isolated from Penicillium sp. Antibiotic. Antifungal penicillide. Non-competitive, specific neutral sphingomyelinase (N-SMase) inhibitor. Strong pp60c-Src inhibitor. Inhibits cFMS receptor tyrosine kinase (CSF-1/m-CSF receptor tyrosine kinase) which is implicated in cancer and bone diseases. Myosin light chain kinase inhibitor. Exhibits anti-HIV-1 integrase activity. Cytotoxic activity against mouse lymphoma cells. Anti-protozoan, trypanothione reductase (TR) inhibitor. Phytotoxin.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur: S. Nakanishi, et al.; Biosci. Biotechnol. Biochem. 59, 1333 (1995) | Alutenusin, a specific neutral sphingomyelinase inhibitor, produced by Penicillium sp. FO-7436: R. Uchida, et al.; J. Antibiot. 52, 572 (1999) | Fungal Metabolites as Potent Protein Kinase Inhibitors: Identification of a Novel Metabolite and Novel Activities of Known Metabolites: M. Oyama, et al.; Lett. Drug Des. Disc. 1, 24 (2004) | HIV-1 Integrase Inhibitors: 2003-2004 Update: R. Dayan, et al.; Med. Res. Rev. 26, 271 (2006) | Altenusin, a biphenyl isolated from the endophytic fungus Alternaria sp. inhibits trypanothione reductase from Trypanosoma cruzi: B.B. Cota, et al.; FEMS Microbiol. Lett. 285, 177 (2008) | Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense: A.H. Aly, et al.; J. Nat. Prod. 71, 972 (2008) | Polyketides with antimicrobial activity from the solid culture of an endolichenic fungus Ulocladium sp.: Q.X. Wang, et al.; Fitoterapia 83, 209 (2012) | Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis: S. Johann, et al.; Rev. Iberoam. Micol. 29, 205 (2012) | Identification of Alternaria alternata mycotoxins by LC-SPE-NMR and their cytotoxic effects to soybean (Glycine max) cell suspension culture: G.D. de Souza, et al.; Molecules 18, 2528 (2013)

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