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Cytisine

Chemicals & Biochemicals

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Article No

AG-CN2-0075-M025

Size

25 mg

Shipping Information

Article No

AG-CN2-0075-M025

Size

25 mg

Specifications

CAS No	485-35-8
MW	190.2
Article No	AG-CN2-0075-M025
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Cytisine
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Chemical. CAS: 485-35-8. Formula: C11H14N2O. MW: 190.2. Isolated from Laburnum anagyroides seeds. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Might be used for binge-like ethanol drinking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.\|Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Might be used for binge-like ethanol drinking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.
Molecular Formula	C11H14N2O
Alias Names	(-)-Cytisine; Baptitoxin; NSC 407282; BRN 0083882
Product Type	Chemicals & Biochemicals
Purity	>99%
Research area	Neuroscience
Shipping Information	RT
Size	25 mg
Solubility	Soluble in ethanol, benzene, acetone or ethyl acetate. Sparingly soluble in water or methanol.
Stability	Stable for at least 2 years after receipt when stored at -20°C.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 485-35-8. Formula: C11H14N2O. MW: 190.2. Isolated from Laburnum anagyroides seeds. Pyridine-like alkaloid. Nicotine agonist. Potent agonist at alpha3beta4 and alpha7 nicotinic acetylcholine receptors and partial agonist at alpha4beta2 nicotinic acetylcholine receptors. Shows analgesic, antihypertensive and inotropic activities. Used for smoking cessation. Might be used for binge-like ethanol drinking cessation. Iron-chelator and hydroxyl radical scavanger. Has antidepressant properties. Used in forensics in novel surface molecular imprinting techniques.
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit: R.L. Papke & S.F. Heinemann; Mol. Pharmacol. 45, 142 (1994) | Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35: B.W. Wenger, et al.; J. Pharmacol. Exp. Ther. 281, 905 (1997) | Effects of cytisine on hydroxyl radicals in vitro and MPTP-induced dopamine depletion in vivo: B. Ferger, et al.; Eur. J. Pharmacol. 360, 155 (1998) | Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors: L.M. Houlihan, et al.; J. Neurochem. 78, 1029 (2001) | Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates: J. Zhang & J.H. Steinbach; Brain Res. 959, 98 (2003) | Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes: Y.E. Slater, et al.; Neuropharmacology 44, 503 (2003) | Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy: P. Tutka & W. Zatonski; Pharmacol. Rep. 58, 777 (2006) (Review) | Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice: Y.S. Mineur, et al.; Neuropharmacology 52, 1256 (2007) | Cytisine for smoking cessation: a research agenda: J.F. Etter, et al.; Drug Alcohol Depend. 92, 3 (2008) (Review) | Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors: Y.F. Li, et al.; Auton. Neurosci. 154, 14 (2010) | Preparation and recognition performance of cytisine alkaloid-imprinted material prepared using novel surface molecular imprinting technique: B. Gao, et al.; J. Sep. Sci. 33, 1338 (2010) | Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice: R.K. Sajja & S. Rahman; Prog. Neuropsychopharmacol. Biol. Psychiatry 35, 257 (2011) | Cytisine improves smoking cessation: W. Osman; Thorax 67, 573 (2011) | Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors: E.G. Perez, et al.; Nat. Prod. Rep. 29, 555 (2012) (Review)

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