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|Country Availability||DK, EE, FI, IS, LT, LV, NO, SE|
|Data Sheet Link||https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/12231|
|Supplier||Adipogen Life Sciences|
|Notes||Chemical. CAS: 444911-05-1. Formula: C20H29NO5S. MW: 395.5. Isolated from marine sponge Negombata magnifica. Antiviral (against herpes simplex type 1 virus (HSV-1)). Cytotoxic. Depolymerizes actin filaments (F-actin).|
|References||Toward computing relative configurations: 16-epi-latrunculin B, a new stereoisomer of the actin polymerization inhibitor latrunculin B: T.R. Hoye, et al.; JACS 124, 7405 (2002) Abstract | A new dimension to the biosynthetic products isolated from the sponge Negombata magnifica: B. Vilozny, et al.; J. Nat. Prod. 67, 1055 (2004) | Diverted total synthesis: Preparation of a focused library of latrunculin analogues and evaluation of their actin-binding properties: A. Fürstner, et al.; PNAS 102, 8103 (2005) | Total syntheses of the actin-binding macrolides latrunculin A, B, C, M, S and 16-epi-latrunculin B: A. Fürstner, et al.; Chemistry 13, 115 (2007) | Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges: T. Amagata, et al.; J. Med. Chem. 51, 7234 (2008)|
|Solubility||Soluble in DMSO or ethanol.|
|Source / Host||fungi|
|Technical Specifications||Antiviral (against herpes simplex type 1 virus (HSV-1)). Cytotoxic. Depolymerizes actin filaments (F-actin).|
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