Products ({{ products.totalElements }})
News & articles ({{ wpNewsAndArticles.total_posts }})
Blog entries ({{ wpBlogEntries.total_posts }})

{{ String(product.attributes.name) }} {{ String(product.attributes.productType) }} - NEW	{{ String(product.attributes.artNo) }}	{{ (String(product.attributes.sizeStr) != 'undefined') ? String(product.attributes.sizeStr) : '–' }}	Not available On Request {{ formatPrice(product.attributes.discountPrice.toString()) }} {{ formatPrice(product.attributes.price.toString()) }} {{ formatPrice(product.attributes.discountPrice.toString()) }} {{ formatPrice(product.attributes.price.toString()) }} Login for price

Full search results →

No products found

News {{ news.date \| formatDate }} #{{tag.name}}

No news & articles found

Full search results →

blog entry {{ blogEntry.date \| formatDate }}

No blog entries found

Full search results →

Nigericin . sodium salt

Chemicals & Biochemicals

Make a customized order

Article No

AG-CN2-0020-M005

Size

5 mg

Shipping Information

Article No

AG-CN2-0020-M005

Size

5 mg

Specifications

CAS No	28643-80-3
MW	724.0 . 23.0
Article No	AG-CN2-0020-M005
Country Availability	SE, FI, DK, NO, IS, EE, LV, LT
Description	Nigericin . sodium salt
Supplier	Adipogen Life Sciences
Format	Powder
Notes	Antibiotic [1]. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+ [2, 3, 4, 7, 10]. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity [3, 6]. Disrupts membrane potential of mitochondria [2]. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release [5, 8, 11, 12]. Autophagy modulator [13]\|Chemical. CAS: 28643-80-3. Formula: C40H67O11 . Na. MW: 724.0 . 23.0. Isolated from Streptomyces hygroscopicus. Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator
Molecular Formula	C40H67O11 . Na
Alias Names	Antibiotic K 178; Helexin C; Polyetherin A; BRN 1696755; Azalomycin M; Antibiotic X-464
Product Type	Chemicals & Biochemicals
Purity	>98%
Research area	Metabolism
Shipping Information	RT
Size	5 mg
Solubility	Soluble in methanol, ethanol, dichlormethane or ethyl acetate. Insoluble in water.
Stability	Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.
Storage	-20°C, 4°C
Technical Specifications	Chemical. CAS: 28643-80-3. Formula: C40H67O11 . Na. MW: 724.0 . 23.0. Isolated from Streptomyces hygroscopicus. Antibiotic. High affinity ionophore for monovalent cations such as H+, K+, Na+, Pb2+. Shows antibacterial (Gram-positive), antifungal, antitumor and antiviral activity. Disrupts membrane potential of mitochondria. NLRP3/NALP3 activator. Signals through pannexin-1 to induce caspase-1 maturation and IL-1beta processing and release. Autophagy modulator
Product Page Updated	2024-02-01T08:25:01.492Z

Documentation

Datasheet

MSDS

References

Nigericin, a new crystalline antibiotic from an unidentified streptomyces: R. L. Harned, et al.; Antibiot. Chemother. 1, 594 (1951) | Potassium Ion-dependent hydrolysis of adenosine triphosphate induced by nigericin in mitochondria: S. Estrada-O, et al.; J. Biol. Chem. 242, 2925 (1967) | Teratogenic effects of nigericin, a carboxylic ionophore: G.C. Vedel-Macrander & R.D. Hood; Teratology 33, 47 (1986) | K+/H+-antiporter nigericin arrests DNA synthesis in Ehrlich ascites carcinoma cells: L.B. Margolis, et al.; PNAS 86, 6626 (1989) | IL-1 beta maturation: evidence that mature cytokine formation can be induced specifically by nigericin: D. Perregaux, et al.; J. Immunol. 149, 1294 (1992) | Antitumor effect of k+/h+-antiporter nigericin on human lung-carcinoma grown in in-vivo-like histocultures: B. Baibakov, et al.; Int. J. Oncol. 3, 1127 (1993) | Nigericin-induced Na+/H+ and K+/H+ exchange in synaptosomes: effect on [3H]GABA release: R. Rodríguez & M. Sitges; Neurochem. Res. 21, 889 (1996) | Activation of interleukin-1beta-converting enzyme by nigericin is independent of apoptosis: N. Watanabe, et al.; Cytokine 10, 645 (1998) | Nigericin inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes: C.Y. Chu, et al.; J. Cell Biochem. 85, 83 (2002) | The ionophore nigericin transports Pb2+ with high activity and selectivity: a comparison to monensin and ionomycin: S.A. Hamidinia, et al.; Biochemistry 43, 15956 (2004) | Cryopyrin activates the inflammasome in response to toxins and ATP: S. Mariathasan, et al.; Nature 440, 228 (2006) | Pannexin-1 couples to maitotoxin- and nigericin-induced interleukin-1beta release through a dye uptake-independent pathway: P. Pelegrin & A. Surprenant; J. Biol. Chem. 282, 2386 (2007) | Nigericin-induced impairment of autophagic flux in neuronal cells is inhibited by overexpression of Bak: J. Lim, et al.; J. Biol. Chem. 287, 23271 (2012)

Shipping info

The delivery time for this item is approximately 5-8 business days. Read more