(+)-Brefeldin A

Article No AG-CN2-0018-M025
Product Type Chemicals & Biochemicals
Research Area Cell Death
Format Powder
Size 25 mg

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Specifications

CAS No 20350-15-6
MW 280.4
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Data Sheet Link https://www.adipogen.com/productmanagement/resource/download/type/sheet/id/12287
Description (+)-Brefeldin A
Supplier Adipogen Life Sciences
Notes Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor (Arf) inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor. Reviews.
Molecular Formula C16H24O4
Alias Names Ascotoxin; Decumbin; Cyanein; Synergisidin
Purity >98% (HPLC)
References Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958) | Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) | Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) | Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992) (Review) | Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) | Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF: J.B. Helms & J.E. Rothman; Nature 360, 352 (1992) | Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002) (Review) | Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective: V. Betina; Folia Microbiol. (Praha) 37, 3 (1992) (Review) | The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro: D.E. Larsson, et al.; Anticancer Res. 30, 149 (2010)
Solubility Soluble in acetone, DMSO, methanol or ethyl acetate (1mg/ml).
Source / Host fungi
Storage -20°C
Technical Specifications Chemical. CAS: 20350-15-6. Formula: C16H24O4. MW: 280.4. Isolated from Penicillium janthinellum. Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor (Arf) inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor. Reviews.
Product Page Updated 2019-01-09T14:34:57.552Z

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