Chemicals & Biochemicals

(+)-Brefeldin A

NEW
(+)-Brefeldin A

Article No

AG-CN2-0018-M010

Size

10 mg

Source / Host

fungi

Shipping Information

Ambient

Product insert

Specifications

CAS No 20350-15-6
MW 280.4
Article No AG-CN2-0018-M010
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Description (+)-Brefeldin A
Supplier Adipogen Life Sciences
Format Powder
Notes Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor (Arf) inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor. Reviews.
Molecular Formula C16H24O4
Alias Names Ascotoxin; Decumbin; Cyanein; Synergisidin
Product Type Chemicals & Biochemicals
Purity >98% (HPLC)
References Decumbin, a new compound from a species of Penicillium: V.L. Singleton, et al.; Nature 181, 1072 (1958) | Novel blockade by brefeldin A of intracellular transport of secretory proteins in cultured rat hepatocytes: Y. Misumi, et al.; J. Biol. Chem. 261, 11398 (1986) | Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum: T. Fujiwara, et al.; J. Biol. Chem. 263, 18545 (1988) | Brefeldin A and the endocytic pathway. Possible implications for membrane traffic and sorting: W. Hunziker, et al.; FEBS Lett. 307, 93 (1992) (Review) | Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53: R.G. Shao, et al.; Exp. Cell Res. 227, 190 (1996) | Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF: J.B. Helms & J.E. Rothman; Nature 360, 352 (1992) | Brefeldin A: deciphering an enigmatic inhibitor of secretion: A. Nebenfuhr, et al.; Plant Physiol. 130, 1102 (2002) (Review) | Biological effects of the antibiotic brefeldin A (decumbin, cyanein, ascotoxin, synergisidin): a retrospective: V. Betina; Folia Microbiol. (Praha) 37, 3 (1992) (Review) | The cytotoxic agents NSC-95397, brefeldin A, bortezomib and sanguinarine induce apoptosis in neuroendocrine tumors in vitro: D.E. Larsson, et al.; Anticancer Res. 30, 149 (2010)
Research Area Cell Death
Shipping Information Ambient
Size 10 mg
Solubility Soluble in acetone, DMSO, methanol or ethyl acetate (1mg/ml).
Source / Host fungi
Stability Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.
Storage -20°C
Technical Specifications Chemical. CAS: 20350-15-6. Formula: C16H24O4. MW: 280.4. Isolated from Penicillium janthinellum. Protein transport from ER to Golgi inhibitor. ADP-ribosylation factor (Arf) inhibitor. Cytotoxic. Antibiotic. Antiviral. Apoptosis inducer. Antitumor compound. Intracellular collagen degradation inhibitor. Reviews.
Product Page Updated 2020-02-11T07:31:00.265Z

Shipping info

The delivery time for this item is approximately 5-8 business days. 
If other deviations occur, this will be noted on the order confirmation or communicated via email.
Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.