Article No
AG-40B-0153-C010
FNDC5:Fc (human) (rec.)
FNDC5:Fc (human) (rec.)
Proteins & Peptides
Specifications
| MW | ~52kDa |
| Article No | AG-40B-0153-C010 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | 0.1 mg/ml |
| Description | FNDC5:Fc (human) (rec.) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <0.01EU/µg purified protein (LAL test). |
| Entrez Gene ID | 252995 |
| Format | Powder |
| Gene Symbol | FNDC5 |
| Notes | Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human).|Protein. FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human). |
| Alias Names | Fibronectin Type III Domain-containing Protein 5; Fibronectin Type III Repeat-containing Protein 2. |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Research area | Metabolism |
| Sequence | FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. |
| Shipping Information | BLUE ICE |
| Size | 10 ug |
| Source / Host | human |
| Species Reactivity | human, mouse, rat |
| Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Lyophilized. Contains PBS. |
| Technical Specifications | Protein. FNDC5 (extracellular domain) (human, aa 32-152 / mouse, aa 29-149) is fused at the C-terminus to the Fc portion of human IgG1. FNDC5 (extracellular domain) has 100% identity between mouse, rat and human. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). Irisin is a recently described exercise and PGC1-alpha-induced myokine secreted by skeletal muscle in mice and humans. Irisin has been shown to induce browning of white adipose tissue, but this role has been questioned and a new function in the control of mass and strength of cortical bone has been reported. The membrane fibronectin type III domain containing protein 5 (FNDC5) can be cleaved by an unknown protease to release the Irisin protein (aa 32-143 for human) and potentially also the FNDC5 (extracellular domain, aa 32-153 for human). |
| UniProt Number | Q8NAU1 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
