Article No
AG-40B-0144-C010
ANGPTL8 [Betatrophin] (mouse) (rec.)
ANGPTL8 [Betatrophin] (mouse) (rec.)
Proteins & Peptides
Specifications
| MW | ~25kDa |
| Article No | AG-40B-0144-C010 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Concentration | 0.1 mg/ml |
| Description | ANGPTL8 [Betatrophin] (mouse) (rec.) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <0.1EU/µg purified protein (LAL test). |
| Entrez Gene ID | 624219 |
| Format | Powder |
| Gene Symbol | Angptl8 |
| Notes | ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.|Protein. Mouse ANGPTL8 [Betatrophin] (16-198) is fused at the N-terminus to a FLAG®-tag. Source: CHO cells. Endotoxin content: 95% (SDS-PAGE). ANGPTL8 (Angiopoietin-like protein 8; RIFL; Lipasin; Betatrophin) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. ANGPTL8 may also function in inhibition of lipase activity and on serum triglyceride regulation. ANGPTL8 is expressed in the liver and in white and brown adipose tissue of mice. In humans, ANGPTL8 is found to be predominantly expressed in the liver. ANGPTL8 levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. ANGPTL8, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8 does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels. |
| Alias Names | Angiopoietin-like Protein 8; ANGPTL8; Lipasin; Refeeding-induced Fat and Liver Protein; RIFL |
| Product Type | Proteins & Peptides |
| Purity | >95% |
| Research area | Metabolism |
| Sequence | Mouse ANGPTL8 [betatrophin] (16-198) is fused at the N-terminus to a FLAG®-tag. |
| Shipping Information | BLUE ICE |
| Size | 10 ug |
| Source / Host | mouse |
| Species Reactivity | mouse |
| Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Lyophilized. Contains PBS + 0.02% CHAPS. |
| Technical Specifications | Protein. Mouse betatrophin (16-198) is fused at the N-terminus to a FLAG®-tag. Source: CHO cells. Endotoxin content: 95% (SDS-PAGE). Betatrophin (RIFL; Lipasin; Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels. |
| UniProt Number | Q8R1L8 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
