Article No
AG-40B-0114-C010
MW | ~70kDa (SDS-PAGE) |
Article No | AG-40B-0114-C010 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Concentration | 0.1 mg/ml |
Description | Angiopoietin-2 (human) (rec.) |
Supplier | Adipogen Life Sciences |
Endotoxin | <0.01EU/µg purified protein (LAL test; Lonza). |
Entrez Gene ID | 285 |
Format | Powder |
Gene Symbol | ANGPT2 |
Notes | Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.|Protein. Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. |
Alias Names | Ang-2; Ang2; Angpt2 |
Product Type | Proteins & Peptides |
Purity | >95% |
Research area | Metabolism |
Sequence | Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag. |
Shipping Information | BLUE ICE |
Size | 10 ug |
Source / Host | human |
Species Reactivity | human, mouse |
Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Lyophilized. Contains PBS with trehalose and Brij35. |
Technical Specifications | Protein. Human angiopoietin-2 (aa 19-496) is fused at the N-terminus to a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context. |
UniProt Number | O15123 |
Product Page Updated | 2024-02-01T08:25:01.492Z |