Article No
AG-40B-0089-3010
MW | ~34kDa (SDS-PAGE) |
Article No | AG-40B-0089-3010 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Concentration | 0.1 mg/ml |
Description | APRIL (mouse) (multimeric) (rec.) MultiPack |
Supplier | Adipogen Life Sciences |
Endotoxin | <0.02EU/µg purified protein (LAL test; Lonza). |
Entrez Gene ID | 69583 |
Format | Powder |
Gene Symbol | Tnfsf13 |
Notes | APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells.|Protein. The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells. |
Alias Names | MultimericAPRIL™; ACRP30headless:APRIL; ACRP30headless:CD256; ACRP30headless:TNFSF13; ACRP30headless:A-proliferation-inducing Ligand: |
Product Type | Proteins & Peptides |
Purity | >95% |
Research Area | Immunology |
Sequence | The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag. |
Shipping Information | BLUE ICE |
Size | 3 x 10 ug |
Source / Host | mouse |
Species Reactivity | human, mouse |
Stability | Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Lyophilized. Contains PBS + 0.5% Trehalose. |
Technical Specifications | Protein. The extracellular domain of mouse APRIL (aa 88-232) is fused at the N-terminus to mouse ACRP30headless (aa 18-110) and a FLAG®-tag. Source: HEK 293 cells. Endotoxin content: 95% (SDS-PAGE). APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumor cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasmablasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulfated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumor cells as well as primary lymphoid cells. |
UniProt Number | Q9D777 |
Product Page Updated | 2024-02-01T08:25:01.492Z |