Article No
AG-40A-0053-C050
IL-33 (mouse) (rec.) (His)
IL-33 (mouse) (rec.) (His)
Proteins & Peptides
Specifications
| MW | ~20kDa (SDS-PAGE) |
| Article No | AG-40A-0053-C050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Description | IL-33 (mouse) (rec.) (His) |
| Supplier | Adipogen Life Sciences |
| Endotoxin | <1EU/µg purified protein (LAL test; Lonza). |
| Entrez Gene ID | 77125 |
| Format | Liquid |
| Gene Symbol | Il33 |
| Notes | Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.|Protein. Mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: 90% (SDS-PAGE). Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
| Alias Names | Interleukin-33; IL-1F11; NF-HEV |
| Product Type | Proteins & Peptides |
| Purity | >90% |
| Research area | Inflammation |
| Sequence | Mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag. |
| Shipping Information | BLUE ICE |
| Size | 50 ug |
| Source / Host | mouse |
| Species Reactivity | human, mouse |
| Stability | Stable for at least 2 years after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. 0.2µm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl. |
| Technical Specifications | Protein. Mouse IL-33 (aa 109-266) is fused at the C-terminus to a His-tag. Source: E. coli. Endotoxin content: 90% (SDS-PAGE). Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
| UniProt Number | Q2YEJ4 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
