Article No
AG-20T-0302-C100
Application | FC, WB |
Article No | AG-20T-0302-C100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | ABM24E5 |
Clone Type | monoclonal |
Concentration | 0.5 mg/ml |
Conjugation | Unconjugated |
Description | anti-TLR3 (mouse), mAb (ABM24E5) |
Supplier | Adipogen Life Sciences |
Format | Liquid |
Immunogen | Recombinant mouse TLR3 protein (aa 180-385). |
Isotype | IgG2b k |
Notes | Monoclonal Antibody. Recognizes mouse TLR3. Isotype: Rat IgG2bkappa. Clone: ABM24E5. Applications: FACS, WB. Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. mTLR3 shows high homology to hTLR3 in their predicted cDNA and protein sequences. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). The high levels of mTLR3 expression in marginal zone B cells perhaps contribute to their ability to clear antigen from the blood. It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia.|TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. mTLR3 shows high homology to hTLR3 in their predicted cDNA and protein sequences. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). The high levels of mTLR3 expression in marginal zone B cells perhaps contribute to their ability to clear antigen from the blood. It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia. |
Alias Names | Toll-like Receptor 3; CD283 |
Product Type | Antibodies Primary |
Purity | Protein G purified. |
Research Area | Immunology |
Shipping Information | BLUE ICE |
Size | 100 ug |
Source / Host | rat |
Species Reactivity | mouse |
Stability | Stable for at least 1 year after receipt when stored at -20°C. Stable for at least 6 months after receipt when stored at +4°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. |
Technical Specifications | Monoclonal Antibody. Recognizes mouse TLR3. Isotype: Rat IgG2bkappa. Clone: ABM24E5. Applications: FACS, WB. Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide. TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. mTLR3 shows high homology to hTLR3 in their predicted cDNA and protein sequences. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). The high levels of mTLR3 expression in marginal zone B cells perhaps contribute to their ability to clear antigen from the blood. It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia. |
Product Page Updated | 2024-02-01T08:25:01.492Z |