Article No
AG-20B-0069-C100
anti-IL-36beta (human), mAb (Jacky-1)
anti-IL-36beta (human), mAb (Jacky-1)
Antibodies Primary
Specifications
| Application | ELISA, WB |
| Article No | AG-20B-0069-C100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | Jacky-1 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | anti-IL-36beta (human), mAb (Jacky-1) |
| Supplier | Adipogen Life Sciences |
| Format | Liquid |
| Immunogen | Recombinant human IL-36beta. |
| Isotype | IgG1 k |
| Notes | IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination.|Monoclonal Antibody. Recognizes human IL-36beta. Does not cross-react with mouse IL-36beta and IL-36gamma. Isotype: Mouse IgG1kappa. Clone: Jacky-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. |
| Alias Names | Interleukin-36beta Interleukin-1 Family Member 8; IL-1F8 |
| Product Type | Antibodies Primary |
| Purity | >95% |
| Research area | Inflammation |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
| Technical Specifications | Monoclonal Antibody. Recognizes human IL-36beta. Does not cross-react with mouse IL-36beta and IL-36gamma. Isotype: Mouse IgG1kappa. Clone: Jacky-1. Applications: ELISA, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. IL-36alpha (IL-1F6), IL-36beta (IL-1F8) and IL-36gamma (IL-1F9) bind to IL-36R (IL-1Rrp2) and IL-1RAcP, activating similar intracellular signals as IL-1. IL-36Ra inhibits the production of proinflammatory cytokines, including IL-12, IL-1beta, IL-6, TNF-alpha and IL-23 induced by IL-36 in BMDC and CD4 T cells. Skin and dendritic cells are targets of the IL-36 interleukins leading to a Th1 response. These cytokines may represent potential targets for immune-mediated inflammatory conditions or, alternatively, could be used as adjuvants in vaccination. |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
