Article No
AG-20B-0056-C100
Application | ICC, IHC, WB |
Article No | AG-20B-0056-C100 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | NF6 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | anti-FLIP (human), mAb (NF6) |
Supplier | Adipogen Life Sciences |
Entrez Gene ID | 8837 |
Format | Liquid |
Gene Symbol | CFLAR |
Immunogen | Recombinant human FLIP (aa 1-480). |
Isotype | IgG1 |
Notes | FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.|Monoclonal Antibody. Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. This antibody recognizes an epitope in the N-terminal DED region (aa1-194). Isotype: Mouse IgG1. Clone: NF6. Applications: ICC, IHC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes. |
Alias Names | I-FLICE; CLARP; CASPER; Usurpin, CASH; FLAME-1 |
Product Type | Antibodies Primary |
Research area | Cell Death |
Shipping Information | BLUE ICE |
Size | 100 ug |
Source / Host | mouse |
Species Reactivity | human |
Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. |
Technical Specifications | Monoclonal Antibody. Recognizes short (FLIPS) and long (FLIPL) splice variants of human FLIP. This antibody recognizes an epitope in the N-terminal DED region (aa1-194). Isotype: Mouse IgG1. Clone: NF6. Applications: ICC, IHC, WB. Liquid. In PBS containing 10% glycerol and 0.02% sodium azide. FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes. |
UniProt Number | O15519 |
Product Page Updated | 2024-02-01T08:25:01.492Z |