Article No
AG-20B-0008PF-C100
anti-LTbetaR (mouse), mAb (4H8 WH2) (preservative free)
anti-LTbetaR (mouse), mAb (4H8 WH2) (preservative free)
Antibodies Primary
Specifications
| Additional Information | The monoclonal antibody to mouse LTbetaR (preservative free) is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2µg/ml. For in vivo use, mice are injected intraperitoneally with 50µg of agonistic MAb to LTbetaR in sterile phosphate saline buffer. |
| Application | Block, FC |
| Article No | AG-20B-0008PF-C100 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | 4H8 WH2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | anti-LTbetaR (mouse), mAb (4H8 WH2) (preservative free) |
| Supplier | Adipogen Life Sciences |
| Entrez Gene ID | 17000 |
| Additional Information | The monoclonal antibody to mouse LTbetaR (preservative free) is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-kappaB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-kappaB2 pathway. For use as an agonist the MAb to LTbetaR is added to cell cultures at 2µg/ml. For in vivo use, mice are injected intraperitoneally with 50µg of agonistic MAb to LTbetaR in sterile phosphate saline buffer. |
| Format | Liquid |
| Gene Symbol | Ltbr |
| Immunogen | Recombinant mouse LTbetaR (cysteine-rich region/aa 31-221). |
| Isotype | IgG2a |
| Notes | Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.|The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. |
| Alias Names | Lymphotoxin-beta Receptor; Tumor Necrosis Factor Receptor 2 Related Protein; Tumor Necrosis Factor C Receptor; Tumor Necrosis Factor Receptor Superfamily Member 3; TNFRSF3 |
| Product Type | Antibodies Primary |
| Protocol | The monoclonal antibody to mouse LTβR (preservative free) is an agonist that can be used for the investigation of the regulation of BAFF (BlyS), chemokines and integrins using in vivo and tissue culture models, the development of NK cells and NK T cells, to study the regulation of NF-κB family of transcription factors in regulation of inflammation and homeostasis, particularly RelB NF-κB2 pathway. For use as an agonist the MAb to LTβR is added to cell cultures at 2μg/ml. For in vivo use, mice are injected intraperitoneally with 50μg of agonistic MAb to LTβR in sterile phosphate saline buffer. |
| Purity | >95% |
| Research area | Immunology |
| Shipping Information | BLUE ICE |
| Size | 100 ug |
| Source / Host | rat |
| Species Reactivity | mouse |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. In PBS containing 10% glycerol. |
| Technical Specifications | Monoclonal Antibody. Recognizes mouse LTbetaR. Isotype: Rat IgG2a. Clone: 4H8 WH2. Applications: FACS, FUNC (Blocking). Liquid. In PBS containing 10% glycerol. The LTbetaR activates two different NF-kappaB pathways that lead to distinct patterns of gene induction, including selected chemokines and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTbetaR activates the classical NF-kappaB (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1beta. However, LTbetaR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival. |
| UniProt Number | P50284 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
