Article No
AG-20A-0091-C050
anti-Sirtuin 6 (human), mAb (S6R82-2)
anti-Sirtuin 6 (human), mAb (S6R82-2)
Antibodies Primary
Specifications
| Application | ELISA, WB |
| Article No | AG-20A-0091-C050 |
| Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
| Clone | S6R82-2 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | anti-Sirtuin 6 (human), mAb (S6R82-2) |
| Supplier | Adipogen Life Sciences |
| Entrez Gene ID | 51548 |
| Format | Liquid |
| Gene Symbol | SIRT6 |
| Immunogen | Recombinant human sirtuin 6. |
| Isotype | IgG2b k |
| Notes | Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha.|Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. |
| Alias Names | SIRT6; NAD-dependent Deacetylase Sirtuin-6; Mono-ADP-ribosyltransferase Sirtuin 6; SIR2-like Protein 6; SIR2L6 |
| Product Type | Antibodies Primary |
| Research area | Metabolism |
| Shipping Information | BLUE ICE |
| Size | 50 ug |
| Source / Host | mouse |
| Species Reactivity | human |
| Stability | Stable for at least 1 year after receipt when stored at -20°C. |
| Storage | -20°C, 4°C |
| Substrate / Buffer | Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
| Technical Specifications | Monoclonal Antibody. Recognizes human sirtuin 6. Detects a band of ~47kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S6R82-2. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin 6 (SIRT6) is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. It modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. It is required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. It also regulates cellular senescence and apoptosis. Unlike most sirtuins, SIRT6 preferentially removes long-chain fatty-acyl, rather than acetyl, protein modifications. This activity regulates secretion of the inflammation-associated protein TNF-alpha. |
| UniProt Number | Q8N6T7 |
| Product Page Updated | 2024-02-01T08:25:01.492Z |
