Article No
AG-20A-0076-C050
Application | ELISA, WB |
Article No | AG-20A-0076-C050 |
Country Availability | SE, FI, DK, NO, IS, EE, LV, LT |
Clone | S2R233-1 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | anti-Sirtuin 2 (human), mAb (S2R233-1) |
Supplier | Adipogen Life Sciences |
Entrez Gene ID | 22933 |
Format | Liquid |
Gene Symbol | SIRT2 |
Immunogen | Recombinant human sirtuin 2. |
Isotype | IgG2b k |
Notes | Monoclonal Antibody. Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S2R233-1. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease.|Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer's disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington's and Parkinson's disease. |
Alias Names | SIRT2; NAD-dependent Deacetylase Sirtuin-2; SIR2-like protein 2; SIR2L2 |
Product Type | Antibodies Primary |
Research Area | Metabolism |
Shipping Information | BLUE ICE |
Size | 50 ug |
Source / Host | mouse |
Species Reactivity | human |
Stability | Stable for at least 1 year after receipt when stored at -20°C. |
Storage | -20°C, 4°C |
Substrate / Buffer | Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. |
Technical Specifications | Monoclonal Antibody. Recognizes human sirtuin 2. Detects a band of ~45kDa by Western blot. Isotype: Mouse IgG2bkappa. Clone: S2R233-1. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. Sirtuin-2 is a NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of a-tubulin. It is involved in the control of mitotic exit in the cell cycle. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. Selective inhibition of Sirtuin-2 achieves neuroprotection and identifies Sirtuin-2 to be a potential therapeutic avenue in Huntington’s and Parkinson’s disease. |
UniProt Number | Q8IXJ6 |
Product Page Updated | 2024-02-01T08:25:01.492Z |