Antibodies Primary

anti-IL-23p40 (human), mAb (I 1108)

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anti-IL-23p40 (human), mAb (I 1108)

Article No

AG-20A-0033-C050

Application

ELISA, WB

Species Reactivity

human

Size

50 µg

Clone

I 1108

Source / Host

mouse

Shipping Information

BI

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Specifications

Application ELISA, WB
Article No AG-20A-0033-C050
Country Availability DK, EE, FI, IS, LT, LV, NO, SE
Clone I 1108
Clone Type monoclonal
Concentration 1mg/ml
Description anti-IL-23p40 (human), mAb (I 1108)
Supplier Adipogen Life Sciences
Format Liquid
Immunogen Recombinant human IL-23p40.
Isotype IgG1 k
Notes Monoclonal Antibody. Recognizes human IL-23p40. Does not cross-react with human IL-23p19. Isotype: Mouse IgG1kappa. Clone: I 1108. Applications: ELISA, WB. Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives. IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).
Alias Names Interleukin-23 Subunit p40; IL-23 Subunit p40; Interleukin-12 Subunit beta IL-12B; Cytotoxic Lymphocyte Maturation Factor 40 kDa Subunit; CLMF p40; IL-12 Subunit p40; NK Cell Stimulatory Factor Chain 2; NKSF2
Product Type Antibodies Primary
Research Area Inflammation
Shipping Information BI
Size 50 µg
Source / Host mouse
Species Reactivity human
Storage -20°C
Substrate / Buffer Liquid. 0.2µm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Technical Specifications IL-23p40 associates with IL-23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Defects in IL-23p40 are a cause of mendelian susceptibility to mycobacterial disease (MSMD). Genetic variations in IL-23p40 are a cause of susceptibility to psoriasis type 11 (PSORS11).
Product Page Updated 2019-07-10T12:23:31.822Z

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