Article No
AFT-DI2KKW-100
Specifications
| MW | 55-70 kDa |
| Application | ELISA, IF, IHC, WB |
| Article No | AFT-DI2KKW-100 |
| Biosite Brand | Biosite |
| Country Availability | all |
| Clone | 9E2 |
| Clone Type | monoclonal |
| Conjugation | Unconjugated |
| Description | KEAP1 antibody |
| Recommended Dilution | IF 1:10-1:100, IHC 1:50-1:500, WB 1:500-1:1000 |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 9817 |
| Format | Liquid |
| Gene Symbol | KEAP1 |
| Immunogen | kelch-like ECH-associated protein 1 |
| Isotype | IgG2a |
| Notes | Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
| Alias Names | INRF2, KIAA0132, KLHL19 |
| Previous Article No | AFT-FAC252 |
| Product Type | Antibodies Primary |
| Purification | Protein A/G Purified |
| Purity | ≥95% |
| Research area | Metabolism |
| Shipping Information | BLUE ICE |
| Size | 100ug |
| Source / Host | mouse |
| Species Reactivity | human, mouse, rat |
| Storage | -20°C |
| UniProt Number | Q14145 |
| Product Page Updated | 2024-02-02T15:01:32.974Z |
