Article No
AFC-G30M7U-100
Anti-Hu CD161 PE-Cy™7
Anti-Hu CD161 PE-Cy™7
Antibodies Primary
Specifications
| Application | FC |
| Article No | AFC-G30M7U-100 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | HP-3G10 |
| Clone Type | monoclonal |
| Conjugation | PE/Cy7 |
| Description | Anti-Hu CD161 PE-Cy™7 |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 3820 |
| Format | PE-Cy™7 |
| Immunogen | human NK cells |
| Isotype | IgG1 k |
| Notes | CD161, also known as Nkrp1 (natural killer receptor protein 1) or Klrb1 (killer cell lectin-like receptor subfamily b member 1), is a disulphide-linked homodimeric receptor, which is involved in regulation of NK cell and NKT cell function. It is expressed on rat NK cells, subset of T cells, dendritic cells, and activated monocytes. Although human CD161 is expressed as one isoform, the rat CD161 has three isoforms, referred to as CD161a, b, and c. These proteins contain C-terminal C-type lectin extracellular domain, a transmembrane domain, and N-terminal intracellular domain, which contains ITIM motif, such as CD161b, and displays inhibitory function, or does not contain ITIM motif, thus also not the inhibitory function, such as CD161a. |
| Alias Names | NKRP1A, KLRB1, CLEC5B |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. |
| Purification | Purified antibody is conjugated with activated tandem dye of R-phycoerythrin-cyanine 7 (PE-Cy™7) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | monkey, human |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody HP-3G10 recognizes an extracellular epitope of CD161, a type II transmembrane C-type lectin receptor, expressed on the plasma membrane of NK cells, dendritic cells, activated monocytes and a subset of T cells as a disulphide-linked homodimer. |
| UniProt Number | Q12918 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
