Antibodies Primary

CD45R0

NEW
Anti-Hu CD45R0 PE-DyLight® 594

Article No

AFC-FB9C2B

Application

FC

Species Reactivity

human

Size

100 tests

Clone

UCHL1

Specifications

Application FC
Article No AFC-FB9C2B
BioSite Brand BioSite Flow
Country Availability all
Clone UCHL1
Clone Type monoclonal
Conjugation PE/DyLight 594
Description Anti-Hu CD45R0 PE-DyLight® 594
Recommended Dilution The purified antibody is conjugated with tandem dye PE-DyLight™ 594 (PE-DL594) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier Nordic BioSite
Immunogen Human IL-2 dependent T cells
Isotype IgG2a
Keywords Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), CD and Related Antigens (Human)
Notes CD45R0 is the shortest isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45R0 is expressed e.g. on macrophages, CD8+ T cells, activated T cells and myeloma cells.
Alias Names PTPRCR, T200R0
Product Type Antibodies Primary
Size 100 tests
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Technical Specifications The antibody UCHL1 recognizes CD45R0, a 180 kDa low molecular weight isoform of the leukocyte common antigen (LCA). The antigen is expressed on a subset of memory/activated T cells and on cortical thymocytes.<br>_x000D_ <b>HLDA III; WS Code NL 826</b><br>_x000D_ <b>HLDA III; WS Code T 128</b><br>_x000D_ <b>HLDA IV; WS Code NL 31</b><br>_x000D_ <b>HLDA V; WS Code BP BP460</b><br>_x000D_ <b>HLDA V; WS Code T T-081</b><br>_x000D_ <b>HLDA V; WS Code T T-CD45.43</b><br>_x000D_ _x000D_
Product Page Updated 2019-11-25T08:14:36.249Z

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