PCNA

Article No AFC-BC2E5C
Product Type Antibodies Primary
Application FC, IP, WB, IHC-P, IHC-Fr, ICC
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone PC10
Clone Type monoclonal
Conjugation PE
Description Mouse Monoclonal to PCNA
Recommended Dilution The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen recombinant rat PCNA
Isotype IgG2a
Keywords Transcription Regulation & Nuclear Proteins (Veterinary), Transcription Regulation & Nuclear Proteins (Rodent), Transcription Regulation & Nuclear Proteins (Human)
Notes PCNA (proliferating cell nuclear antigen), which is the DNA polymerase delta auxiliary protein acting in homotrimeric form to increase the processivity of leading strand synthesis during DNA replication. PCNA is expressed in the nucleus of all proliferating cells. In response to DNA damage, it is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. PCNA is a useful marker of DNA synthesis, as its form not involved in DNA synthesis degradates in histological preparations in the presence of organic solvents.
Species Reactivity human, monkey, mouse, rat, chicken
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The mouse monoclonal antibody PC10 (also known as 3F81) recognizes PCNA, a 36 kDa conserved nuclear protein serving as a cofactor for DNA synthesis.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

human, monkey, mouse, rat, chicken human monkey mouse rat