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Anti-Hu CD334 Purified

Antibodies Primary

Make a customized order

Article No

AFC-XRH2R9-0.1

Species Reactivity

human

Size

0.1 mg

Clone

4FR6D3

Source / Host

mouse

Application

FC, ICC

Article No

AFC-XRH2R9-0.1

Species Reactivity

human

Size

0.1 mg

Clone

4FR6D3

Source / Host

mouse

Application

FC, ICC

Specifications
Suggested protocols
References

Specifications

Application	FC, ICC
Article No	AFC-XRH2R9-0.1
Biosite Brand	Biosite Flow
Country Availability	all
Clone	4FR6D3
Clone Type	monoclonal
Concentration	1 mg/ml
Conjugation	Unconjugated
Description	Anti-Hu CD334 Purified
Supplier	Nordic Biosite
Entrez Gene ID	2264
Format	Purified
Immunogen	NIH 3T3 cells transfected with full length human CD334
Isotype	IgG1 k
Keywords	Cytokine Signaling (Human), CD and Related Antigens (Human)
Notes	CD334 / FGFR4 (fibroblast growth factor receptor 4), a transmembrane tyrosine kinase, which is expressed in many tissues, such as in lung, kidney, muscle, heart, pancreas, intestine and other, acts as a receptor for several fibroblast growth factors, namely FGF1, FGF2, FGF6, FGF8, and FGF19. Interaction with these growth factors initiates in cell the signaling cascades leading to the mitogenesis and cell differentiation. Presence of CD334 Gly338Arg allele correlates with prognostic parameters in various cancer studies. CD334 plays multiple roles in the organism, including those of muscle regeneration, cholesterol-to-bile acid metabolism, or glucose homeostasis.
Alias Names	FGFR4, TKF, JTK2, FGFR-4
Previous Article No	AFC-B09A00, AFC-XRH2R9-0.1
Product Type	Antibodies Primary
Protocol	Flow cytometry: Recommended dilution: 2-6 μg/ml.
Purification	Purified by protein-A affinity chromatography.
Purity	> 95% (by SDS-PAGE)
Size	0.1 mg
Source / Host	mouse
Species Reactivity	human
Storage	Store at 2-8°C. Do not freeze.
Substrate / Buffer	Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Technical Specifications	The mouse monoclonal antibody 4FR6D3 reacts with an extracellular epitope of CD334, the fibroblast growth factor receptor 4, which is an approximately 88 kDa receptor tyrosine kinase expressed in variety of tissues.
UniProt Number	P22455
Product Page Updated	2024-01-03T12:18:20.318Z

Suggested protocols

Flow Cytometry

References

*Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R: Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4978-86., URL: https://www.ncbi.nlm.nih.gov/pubmed/24297935,*Masuda H, Anwar SS, Bühring HJ, Rao JR, Gargett CE: A novel marker of human endometrial mesenchymal stem-like cells. Cell Transplant. 2012;21(10):2201-14., URL: https://pubmed.ncbi.nlm.nih.gov/22469435/,,*Huang X, Yang C, Luo Y, Jin C, Wang F, McKeehan WL: FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes. 2007 Oct;56(10):2501-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/17664243?itool,*Zhao P, Caretti G, Mitchell S, McKeehan WL, Boskey AL, Pachman LM, Sartorelli V, Hoffman EP: Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway. J Biol Chem. 2006 Jan 6;281(1):429-38., URL: https://www.ncbi.nlm.nih.gov/pubmed/16267055?itool,*Yang YC, Lu ML, Rao JY, Wallerand H, Cai L, Cao W, Pantuck A, Dalbagni G, Reuter V, Figlin RA, Belldegrun A, Cordon-Cardo C, Zhang ZF: Joint association of polymorphism of the FGFR4 gene and mutation TP53 gene with bladder cancer prognosis. Br J Cancer. 2006 Dec 4;95(11):1455-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/17088904?itool,*Bange J, Prechtl D, Cheburkin Y, Specht K, Harbeck N, Schmitt M, Knyazeva T, Müller S, Gärtner S, Sures I, Wang H, Imyanitov E, Häring HU, Knayzev P, Iacobelli S, Höfler H, Ullrich A: Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. Cancer Res. 2002 Feb 1;62(3):840-7., URL: https://www.ncbi.nlm.nih.gov/pubmed/11830541?itool,*Vainikka S, Partanen J, Bellosta P, Coulier F, Birnbaum D, Basilico C, Jaye M, Alitalo K: Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction. EMBO J. 1992 Dec;11(12):4273-80., URL: https://www.ncbi.nlm.nih.gov/pubmed/1385111?itool=,*Partanen J, Mäkelä TP, Eerola E, Korhonen J, Hirvonen H, Claesson-Welsh L, Alitalo K: FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. EMBO J. 1991 Jun;10(6):1347-54., URL: https://www.ncbi.nlm.nih.gov/pubmed/1709094?itool=,,

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