CD274 / PD-L1

Article No AFC-8D1349
Product Type Antibodies Primary
Application FC, IHC-Fr, FA
Size 0.1 mg


Country Availability all
BioSite Brand BioSite Flow
Clone 29E.2A3
Clone Type monoclonal
Conjugation Unconjugated
Description Mouse Monoclonal to CD274 / PD-L1
Supplier BioSite Flow
Immunogen Full length human CD274
Isotype IgG2b
Keywords CD and Related Antigens (Human)
Notes CD274 / PD-L1 (programmed death ligand-1), also known as B7-H1, is a member of the B7 family of regulatory proteins. It can act as both costimulatory and coinhibitory molecule for T cells. Interaction with its ligand CD279 (PD1) appears to be important in the maintenance of peripheral tolerance and in prevention of tumor rejection. Even pathogens (e.g. Schistosoma) may exploit CD274 to evade an immune response. Besides CD279, existence of other receptor(s) for CD274 is likely.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The mouse monoclonal antibody 29E.2A3 recognizes CD274 / PD-L1 (also known as B7-H1), a 40 kDa type I transmembrane protein expressed by dendritic cells, activated T cells, activated monocytes, and in various tissues, above all in heart and skeletal muscle, placenta and lung, and in many cancer cells, including T cell lymphomas, melanomas, and glioblastomas.
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, monkey human monkey