Article No
AFC-YPTIQ9-0.1
Anti-Hu CD11b (activation epitope) Purified
Anti-Hu CD11b (activation epitope) Purified
Antibodies Primary
Specifications
| Application | FC, IP |
| Article No | AFC-YPTIQ9-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | CBRM1/5 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD11b (activation epitope) Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 3684 |
| Format | Purified |
| Immunogen | Information not available |
| Isotype | IgG1 k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. |
| Alias Names | Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A |
| Previous Article No | AFC-873D76, AFC-YPTIQ9-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 1-4 µg/ml |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody CBRM1/5 recognizes an activation-dependent epitope on extracellular part of CD11b (Mac-1alpha), a 165-170 kDa type 1 transmembrane protein mainly expressed on monocytes, granulocytes and NK-cells. The antibody recognizes a subset of CD11b molecules on neutrophils and monocytes activated with chemoattractants or phorbol esters and it does not recognize CD11b on non-activated cells. |
| UniProt Number | P11215 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
