Article No
AFC-TLJYMC-0.1
Application | FC, IP, IHC |
Article No | AFC-TLJYMC-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | M1/70 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Ms CD11b Purified |
Supplier | Nordic Biosite |
Entrez Gene ID | 16409 |
Format | Purified |
Immunogen | B10 mouse spleen cells enriched for T cells |
Isotype | IgG2b |
Keywords | CD Antigens & MHC (Veterinary), CD and Related Antigens & MHC (Rodent) |
Notes | CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. |
Alias Names | Mac-1, Integrin alpha M, ITGAM, CR3A, MO1A, MAC1A |
Previous Article No | AFC-6B1197, AFC-TLJYMC-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 1 μg/ml. |
Purification | Purified by protein-G affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | mouse, rabbit, human, monkey |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Technical Specifications | The rat monoclonal antibody M1/70 detects an extracellular epitope of CD11b (integrin alphaM subunit), a type I transmembrane protein mainly expressed on monocytes/macrophages, granulocytes and NK-cells, which associates with CD18 to form Mac-1 integrin that plays important role in cell-cell interactions. |
UniProt Number | G5E8F1 |
Product Page Updated | 2024-01-03T12:18:20.318Z |