CD49b / Integrin alpha 2

Article No AFC-67E387
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC-Fr, ICC, ELISA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone AK7
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Unconjugated
Description Mouse Monoclonal to CD49b / Integrin alpha 2
Supplier BioSite Flow
Immunogen Human platelets
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD49b / Integrin alpha 2 (ITGA2; alpha 2 subunit of VLA-2) heterodimerizes with CD29 to form the VLA-2 integrin alpha2/beta1 complex, which serves as a receptor for type I collagen, laminin, and E-cadherin. It also acts as a receptor for echovirus. Expressed on platelets, activated lymphocytes, monocytes, fibroblasts, epitelial and endothelial cells, CD49b mediates adhesion of these cells to the extracellular matrix. This interaction supports e.g. T cell proliferation and cytokine production, or wound healing. Defect in CD49b is associated with bleeding disorder platelet-type 9. Antibodies against CD49b are found in several immune disorders, including neonatal alloimmune thrombocytopenia.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The mouse monoclonal antibody AK7 recognizes CD49b, a 160-165 kDa alpha subunit of VLA-2 integrin complex expressed on platelets, megakaryocytes, activated T and B cells, monocytes, epithelial cells, endothelial cells and fibroblasts._x000D_ <br>_x000D_ <b>HLDA Workshop code V S190</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, monkey human monkey