Antibodies Primary

CD7

NEW
Anti-Hu CD7 PE-DyLight® 594

Article No

AFC-5601-2

Application

FC

Species Reactivity

human

Size

100 tests

Clone

MEM-186

Specifications

Application FC
Article No AFC-5601-2
BioSite Brand BioSite Flow
Country Availability all
Clone MEM-186
Clone Type monoclonal
Conjugation PE/DyLight 594
Description Anti-Hu CD7 PE-DyLight® 594
Recommended Dilution The purified antibody is conjugated with tandem dye PE-DyLight™ 594 (PE-DL594) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier Nordic BioSite
Entrez Gene ID 924
Immunogen Human acute myelogenous leukaemia cell line KG-1.
Isotype IgG
Keywords CD and Related Antigens (Human)
Notes CD7, also known as gp40, is a member of the immunoglobulin superfamily found on T cells, NK cells, thymocytes, hematopoietic progenitors, and monocytes (weakly). CD7 is also expressed on acute lymphocytic leukemia (ALL). CD7 crosslinking induces a calcium flux in T lymphocytes, presumably as a result of cytoplasmic domain association with PI3-kinase. CD7 co-stimulation can induce cytokine secretion and modulate cellular adhesion. A ligand of CD7, epithelial cell secreted protein K12, is produced in thymus to regulate thymocyte signaling and cytokine release. In lung microvascular endothelial cells CD7 serves as an IgM Fc receptor. Expression of CD7 is an important marker used in leukemia diagnostics.
Alias Names GP40, TLA, TP41, LEU-9
Product Type Antibodies Primary
Research Area Immunology
Size 100 tests
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Technical Specifications The MEM-186 antibody reacts with CD7, a 40 kD type I transmembrane glycoprotein expressed on peripheral blood T lymphocytes, NK-cells, hematopoietic progenitors, monocytes (weakly) and also on acute lymphocytic leukemia.<br><b>HLDA VI; WS Code T 6T-015</b><br>_x000D_
UniProt Number P09564
Product Page Updated 2019-11-25T08:14:36.249Z

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