Antibodies Primary

CD243

NEW
Mouse Monoclonal to CD243 / MDR-1

Article No

AFC-53D352

Application

FC, IP, IHC, IHC, FA

Species Reactivity

human

Size

100 tests

Clone

UIC2

Specifications

Application FC, IP, IHC, IHC, FA
Article No AFC-53D352
BioSite Brand BioSite Flow
Clone UIC2
Clone Type monoclonal
Conjugation PE
Description Mouse Monoclonal to CD243 / MDR-1
Recommended Dilution The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen NIH 3T3 cells transfected with human CD243 (MDR-1) cDNA
Isotype IgG2a
Keywords CD and Related Antigens (Human)
Notes CD243, also known as multidrug resistant protein 1 (MDR-1) or P-glycoprotein (Pgp) is an ATP binding cassette (ABC)-containing efflux transporter for xenobiotic lipophilic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in many tissues, including the brain, liver, pancreas, testes, kidney, and blood (B, T, NK cells, but not monocytes).
Product Type Antibodies Primary
Research Area Immunology
Size 100 tests
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The mouse monoclonal antibody UIC2 recognizes an extracellular epitope on CD243 (MDR-1), an approximately 170 kDa ABC transporter expressed on hematopoietic stem cells, B, T, and NK cells, or on many multidrug resistant cancer cells. This antibody preferentially recognizes CD243 in the process of transporting substrate._x000D_ <br><br>_x000D_ <b>7th International HLDA Workshop</b>
Product Page Updated 2019-05-20T06:41:23.567Z

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