PCLO

Article No AFC-5298-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, WB
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone PCLO-01
Clone Type monoclonal
Concentration 0.1 mg/ml
Conjugation PE
Description Mouse Monoclonal to PCLO
Recommended Dilution The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
Supplier BioSite Flow
Immunogen Human recombinant PCLO protein
Isotype IgG1
Keywords Adaptor Proteins (Human), Neurobiology (Human)
Notes PCLO (piccolo, also known as aczonin) is a large (more than 400 kDa) multidomain protein of the presynaptic cytomatrix in neurons, that is present in all vertebrate synapses, but is absent from invertebrates. It contains zinc finger and coiled-coil sequences, as well as N-terminal glutamine-rich sequence, and C-terminal PDZ domain followed by two C2 domains (C2A and C2B). In vitro binding and transfection experiments suggested that PCLO binds to multiple proteins including profilin and L-type calcium channels. It is involved in neurotransmitter release and insulin secretion.
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The mouse monoclonal antibody PCLO-01 recognizes PCLO (Piccolo), a more than 400 kDa multidomain protein expressed mainly in the presynaptic cytomatrix of the neurons.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

human human

Suggested protocols:

Western Blot

Western Blot