Article No
AFC-ZKXSNM-100
Specifications
| Application | FC |
| Article No | AFC-ZKXSNM-100 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | DBN-N-03 |
| Clone Type | monoclonal |
| Conjugation | PE |
| Description | Anti-Drebrin PE |
| Recommended Dilution | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 1627 |
| Format | PE |
| Immunogen | Bacterially expressed N-terminal fragment of recombinant human drebrin (aa 1-326) |
| Isotype | IgG2b |
| Keywords | Neurobiology (Human), Cytoskeleton: Actin System (Human) |
| Notes | Drebrin is an actin-binding protein, which is expressed mainly in neurons and plays important role in their morphogenesis. The highest level of its expression is in developing brain. Both in neurons and non-neuronal cells drebrin acts as a key regulator of actin cytoskeleton remodelling, affecting especially intercellular junctions, such as dendritic spines of neurons or the immune synapses of T cells. Decrease of drebrin amount in the brain seems to be associated with Alzheimer's disease and Down syndrome, and in case of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) lower drebrin expression correlates with higher risk of relapse. |
| Alias Names | DBN, D0S117E |
| Previous Article No | AFC-5295-2 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: The reagent is designed for analysis of human blood cells using 4 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (0.4 ml) is sufficient for 100 tests. Intracellular staining. |
| Purification | Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography. |
| Research area | Neuroscience |
| Size | 100 tests |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze. |
| Substrate / Buffer | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody DBN-N-03 recognizes drebrin, an approximately 100-125 kDa intracellular regulator of actin cytoskeleton. |
| UniProt Number | Q16643 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
