Antibodies Primary

CD50

NEW
Mouse Monoclonal to CD50 / ICAM-3

Article No

AFC-5142-2

Application

FC, IP

Species Reactivity

human

Size

100 tests

Clone

MEM-171

Suggested protocols

Specifications

Application FC, IP
Article No AFC-5142-2
BioSite Brand BioSite Flow
Clone MEM-171
Clone Type monoclonal
Conjugation PE
Description Mouse Monoclonal to CD50 / ICAM-3
Recommended Dilution The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen Human granulocytes
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD50 (intracellular adhesion molecule 3, ICAM-3) is a transmembrane glycoprotein expressed by leukocytes, that serves as a counter-receptor for the lymphocyte function-associated antigen (LFA)-1 integrin. Besides functioning as an adhesive molecule that mediates e.g. the contact between T cells and antigen presenting cells, ICAM-3 regulates affinity of LFA-1 for ICAM-1 and induces T cell activation and proliferation. ICAM-3 plays an essential role in the initiation of the immune response both on T cells and antigen presenting cells and interacts also with CD209 (dendritic cell-specific ICAM-3-grabbing nonintegrin, DC-SIGN), a C-type lectin of dendritic cells and macrophages; this process is involved in dialogue between dendritic cells and granulocytes.
Product Type Antibodies Primary
Research Area Immunology
Size 100 tests
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody MEM-171 recognizes an epitope in the D2 domain of CD50 (ICAM-3), a 120-130 kDa type I membrane protein (immunoglobulin supergene family) expressed on leukocytes, endothelial cells and Langerhans cells; it is negative on platelets and erythrocytes. <br>_x000D_ <b>HLDA VI; WS Code BP 614<br>_x000D_ HLDA VI; WS Code NL N-L022</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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