Antibodies Primary

CD45

NEW
Anti-Hu CD45 PE

Article No

AFC-5125-2

Application

FC

Species Reactivity

human

Size

100 tests

Clone

MEM-28

Specifications

Application FC
Article No AFC-5125-2
BioSite Brand BioSite Flow
Country Availability all
Clone MEM-28
Clone Type monoclonal
Conjugation PE
Description Anti-Hu CD45 PE
Recommended Dilution The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier Nordic BioSite
Entrez Gene ID 5788
Immunogen Human thymocytes and T lymphocytes.
Isotype IgG1
Keywords Phosphorylation (Kinases, Phosphatases, Phosphotyrosine) (Human), CD and Related Antigens (Human)
Notes CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis.
Alias Names LCA, Receptor-type tyrosine-protein phosphatase C, Leukocyte common antigen, L-CA, T200, LY5, B220, GP180
Product Type Antibodies Primary
Size 100 tests
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
Technical Specifications The antibody MEM-28 reacts with all alternative forms of human CD45 antigen (Leukocyte Common Antigen), a 180-220 kDa single chain type I transmembrane protein expressed at high level on all cells of hematopoietic origin, except erythrocytes and platelets. <br>_x000D_ <b>HLDA III; WS Code NL 833a</b>
UniProt Number P08575
Product Page Updated 2019-11-25T08:14:36.249Z

Shipping info

The delivery time for this item is approximately 5-8 business days. 
If other deviations occur, this will be noted on the order confirmation or communicated via email.
Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.