CD44

Article No AFC-5044-1
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC-P, IHC-Fr, ICC
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone IM7
Clone Type monoclonal
Concentration 0.5 mg/ml
Conjugation FITC
Description Rat Monoclonal to CD44
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
Supplier BioSite Flow
Immunogen Dexamethasone-induced cells of the SJL mouse spontaneous myeloid leukemia M1_x000D_
Isotype IgG2b
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Notes CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells._x000D_
Species Reactivity human, mouse, dog/canine, horse/equine, cat/feline
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The rat monoclonal antibody IM7 reacts with CD44 antigen (Phagocyte glycoprotein 1), an 80-95 kDa transmembrane glycoprotein (hyaladherin family) present on the most of cells and tissues (leukocytes, endothelial cells, mesenchymal cells, etc.); it is negative on platelets and hepatocytes. The antibody reacts with all isoforms of mouse CD44._x000D_
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, mouse, dog/canine, horse/equine, cat/feline human mouse