CD3 zeta (CD247)

Article No AFC-5028-1
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, ICC
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone H146-968
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation FITC
Description Hamster Monoclonal to CD3 zeta (CD247)
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC.
Supplier BioSite Flow
Immunogen Synthetic peptide corresponding to amino acids 151-164 of mouse CD3 zeta. _x000D_
Isotype IgG2
Keywords CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Notes CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.
Species Reactivity human, mouse
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
Technical Specifications The Armenian hamster antibody H146-968 reacts with CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

The delivery time for this item is approximately 5-8 business days. If other deviations occur, this will be noted on the order confirmation or communicated via email. Please note, we do reserve the right to select the best packaging and shipping method in order to insure the stability of the product and allow efficient order tracking.

Species reactivity:

human, mouse human mouse