CD86

Article No AFC-5021-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC-Fr, FA
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone BU63
Clone Type monoclonal
Conjugation FITC
Description Mouse Monoclonal to CD86
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen B-lymphoblastoid cell line ARH 77_x000D_
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response._x000D_
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody BU63 reacts with CD86 (B7-2), a 70 kDa type I transmembrane glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.<br>_x000D_ <b>HLDA V; WS Code BP BP072<br>_x000D_ HLDA V; WS Code A A109<br>_x000D_ HLDA VI; WS Code BP 95<br>_x000D_ HLDA VI; WS Code B CD86.9</b>_x000D_
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human