CD1a

Article No AFC-4984-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IHC-Fr
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone HI149
Clone Type monoclonal
Conjugation FITC
Description Mouse Monoclonal to CD1a
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen Human thymocytes
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.
Species Reactivity human
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody HI149 reacts with CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. <br>The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes. <br><b>HLDA V; WS Code CD01.01</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human