CD222

Article No AFC-4975-2
Product Type Antibodies Primary
Research Area Cell Signaling
Application FC, IP, WB
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone MEM-238
Clone Type monoclonal
Conjugation FITC
Description Mouse Monoclonal to CD222 / IGF2 receptor / CIMPR
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen Recombinant <i>Vaccinia</i> virus encoding CD222.
Isotype IgG1
Keywords Cytokine Signaling (Human), CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD222 (CIMPR, cation-independent mannose 6-phosphate receptor; IGF2 receptor) is a ubiquitously expressed 250 kDa transmembrane protein. No more than 10% of CD222 is present on the cell surface where it serves as a multifunctional receptor. Intracellular (major) fraction of CD222 is involved in transport of newly synthesized lysosomal enzymes modified by mannose 6-phosphate from Golgi apparatus to lysosomes. The cell surface CD222 binds and internalizes exogeneous mannose 6-phosphate-containing ligands. Importantly, CD222 is crutial for internalization and degradation of insulin-like growth factor 2, thus controling cell growth. CD222 also complexes CD87 (urokinase-type plasminogen-activator receptor), plasminogen and latent TGF-beta, last but not least CD222 serves as a receptor for heparanase and even for Listeria.
Species Reactivity human, monkey
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody MEM-238 recognizes an epitope between amino acids 192-697 of CD222 (IGF2 receptor), a ubiquitously expressed 250 kDa multifunctional type I transmembrane protein. The majority of CD222 is found in the late endosomal/prelysosomal compartment, 5-10% in the plasma membrane and the truncated (220 kDa) form of CD222 is present in human and bovine serum._x000D_ <br>_x000D_ <b>HLDA VII; WS Code 70640<br>_x000D_ </b>_x000D_
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, monkey human monkey