Antibodies Primary

CD21

NEW
Mouse Monoclonal to CD21

Article No

AFC-4971-2

Application

FC, IHC

Species Reactivity

human
pig/porcine
cow/bovine
dog/canine

Size

100 tests

Clone

LT21

Suggested protocols

Specifications

Application FC, IHC
Article No AFC-4971-2
BioSite Brand BioSite Flow
Clone LT21
Clone Type monoclonal
Conjugation FITC
Description Mouse Monoclonal to CD21
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen IM9 human B-lymphoblastoid cell line
Isotype IgG1
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
Product Type Antibodies Primary
Research Area Immunology
Size 100 tests
Species Reactivity human, pig/porcine, cow/bovine, dog/canine
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.<br>_x000D_ <b>HLDA VI; WS Code B CD21.1</b>
Product Page Updated 2019-05-16T11:08:57.063Z

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