CD21

Article No AFC-4971-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IHC-Fr
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone LT21
Clone Type monoclonal
Conjugation FITC
Description Mouse Monoclonal to CD21
Recommended Dilution The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen IM9 human B-lymphoblastoid cell line
Isotype IgG1
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD21 (complement receptor 2, CR2) binds C3 complement fragments, especially its breakdown fragments, which remain covalently attached to complement activating surfaces or antigen. CD21 has important roles in uptake and retention of immunocomplexes, survival of memory B cells and in development and maintenance of the humoral response to T-dependent antigens. CD21 also serves as a key receptor for Epstein-Barr virus binding and is involved in targeting prions to folicular dendritic cells and expediting neuroinvasion following peripheral exposure to prions. A soluble form of the CD21 (sCD21) is shed from the lymphocyte surface and retains its ability to bind respective ligands.
Species Reactivity human, pig/porcine, cow/bovine, dog/canine
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The antibody LT21 reacts with CD21 (CR2), a 145 kDa transmembrane glycoprotein (complement C3d receptor - C3dR) expressed on B lymphocytes, follicular dendritic cells, some epithelial cells and a subsets of T lymphocytes. It is not expressed on immature B cells.<br>_x000D_ <b>HLDA VI; WS Code B CD21.1</b>
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human, pig/porcine, cow/bovine, dog/canine human