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Anti-Hu CD108 FITC

Antibodies Primary

Make a customized order

Article No

AFC-JC43XZ-100

Application

Species Reactivity

human

Size

100 tests

Clone

MEM-150

Source / Host

mouse

Article No

AFC-JC43XZ-100

Application

Species Reactivity

human

Size

100 tests

Clone

MEM-150

Source / Host

mouse

Specifications
Suggested protocols
References

Specifications

Application	FC
Article No	AFC-JC43XZ-100
Biosite Brand	Biosite Flow
Country Availability	all
Clone	MEM-150
Clone Type	monoclonal
Conjugation	FITC
Description	Anti-Hu CD108 FITC
Recommended Dilution	The purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
Supplier	Nordic Biosite
Entrez Gene ID	8482
Format	FITC
Immunogen	HPB-ALL human T cell line
Isotype	IgM
Keywords	Blood Group Antigens (Human), CD and Related Antigens (Human)
Notes	CD108 (Sema7A) is a GPI-anchored semaphorin family member, which enhances central and peripheral axonal growth and is required for proper axon track formation during ebryogenesis. CD108 also regulates osteoclast differentiation and pre-osteoblastic cell migration, and in immune system affects cell proliferation, chemotaxis and cytokine release. On erythrocytes CD108 defines the JMH (John-Milton-Hagen) human blood group. CD108 signalizes through its receptors – plexin C1 and beta1 integrins.
Alias Names	Semaphorin 7a, JMH blood group antigen, SEMAL, SEMAK1
Previous Article No	AFC-4962-2
Product Type	Antibodies Primary
Protocol	Flow cytometry: The reagent is designed for analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (2 ml) is sufficient for 100 tests.
Purification	Purified antibody is conjugated with fluorescein isothiocyanate (FITC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Research area	Immunology
Size	100 tests
Source / Host	mouse
Species Reactivity	human
Storage	Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Substrate / Buffer	Stabilizing Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
Technical Specifications	The antibody MEM-150 reacts with CD108 (JMH blood group antigen), a 80 kDa GPI-anchored extracellular glycoprotein expressed on various cell types including erythrocytes, lymphoblasts; at low levels it is present on circulating lymphocytes.
UniProt Number	O75326
Product Page Updated	2024-01-03T12:18:20.318Z

Suggested protocols

Flow Cytometry

References

*Angelisova P, Drbal K, Cerny J, Hilgert I, Horejsi V: Characterization of the human leukocyte GPI-anchored glycoprotein CDw108 and its relation to other similar molecules. Immunobiology. 1999 Jun;200(2):234-45., URL: https://www.ncbi.nlm.nih.gov/pubmed/10416131?dopt=,*Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997)., URL: ,*Leukocyte Typing V., Schlossman S. et al. (Eds.), Oxford University Press (1995)., URL: ,*Mudad R, Rao N, Angelisova P, Horejsi V, Telen MJ.: Evidence that CDw108 membrane protein bears the JMH blood group antigen. Transfusion. 1995 Jul;35(7):566-70. , URL: https://www.ncbi.nlm.nih.gov/pubmed/7631388?dopt=A,,*Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL: Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405., URL: https://www.ncbi.nlm.nih.gov/pubmed/12879062?ordin,*Delorme G, Saltel F, Bonnelye E, Jurdic P, Machuca-Gayet I: Expression and function of semaphorin 7A in bone cells. Biol Cell. 2005 Jul;97(7):589-97., URL: https://www.ncbi.nlm.nih.gov/pubmed/15859945?ordin,*Pasterkamp RJ, Kolk SM, Hellemons AJ, Kolodkin AL: Expression patterns of semaphorin7A and plexinC1 during rat neural development suggest roles in axon guidance and neuronal migration. BMC Dev Biol. 2007 Aug 29;7:98., URL: https://www.ncbi.nlm.nih.gov/pubmed/17727705?ordin,*Suzuki K, Okuno T, Yamamoto M, Pasterkamp RJ, Takegahara N, Takamatsu H, Kitao T, Takagi J, Rennert PD, Kolodkin AL, Kumanogoh A, Kikutani H: Semaphorin 7A initiates T-cell-mediated inflammatory responses through alpha1beta1 integrin. Nature. 2007 Apr 5;446(7136):680-4., URL: https://www.ncbi.nlm.nih.gov/pubmed/17377534?ordin,,

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