Antibodies Primary

CD3

NEW
Mouse Monoclonal to CD3

Article No

AFC-4896-1

Application

FC, IP, IHC, FA

Species Reactivity

human
monkey

Size

0.1 mg

Clone

UCHT1

Suggested protocols

Specifications

Application FC, IP, IHC, FA
Article No AFC-4896-1
BioSite Brand BioSite Flow
Clone UCHT1
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Biotin
Description Mouse Monoclonal to CD3
Recommended Dilution The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Supplier BioSite Flow
Immunogen human thymocytes followed by Sezary T cells
Isotype IgG1
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens (Human)
Notes CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation._x000D_ The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.
Product Type Antibodies Primary
Research Area Immunology
Size 0.1 mg
Species Reactivity human, monkey
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.4
Technical Specifications The antibody UCHT1 recognizes the CD3 antigen of the TCR/CD3 complex on mature human T cells. The UCHT1 antibody reacts with the epsilon chain of the CD3 complex. <br>_x000D_ <b>HLDA I; WS Code T 3<br>_x000D_ HLDA III; WS Code T 126<br>_x000D_ HLDA III; WS Code T 471<br>_x000D_ HLDA VI; WS Code T 6T-CD3.1</b>
Product Page Updated 2019-05-16T11:08:57.063Z

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