Article No
AFC-ZPMNXU-0.1
Specifications
| Application | FC, IP, IHC |
| Article No | AFC-ZPMNXU-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | MEM-108 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Biotin |
| Description | Anti-Hu CD98 Biotin |
| Recommended Dilution | The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 8140 |
| Format | Biotin |
| Immunogen | RAJI human Burkitt's lymphoma cell line |
| Isotype | IgG1 |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD98 (4F2) is a type II transmembrane glycoprotein which serves as the heavy chain of the heterodimeric amino acid transporters (HATs). CD98, linked to various light chains by disulfide bond, is responsible for cell surface expression and basolateral localization of this transporter complex in polarized epithelial cells and also interacts with beta1 integrins and increases their affinity for ligand. Besides its roles in amino acid transport, CD98 is thus involved in cell fusion and activation. It is implicated in regulation of cellular differentiation, growth and apoptosis. |
| Alias Names | 4F2, MDU1, 4F2HC, 4T2HC, NACAE, SLC3A2 |
| Previous Article No | AFC-4865-2, AFC-ZPMNXU-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 3 μg/ml. |
| Purification | Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography. |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The antibody MEM-108 reacts with an extracellular epitope of CD98, a 125 kDa disulfide-linked heterodimer (80 kDa glycosylated heavy chain + 45 kDa non-glykosylated light chain). CD98 is expressed on T lymphocytes (upon activation) and activated NK cells; it is also present at low levels on B lymphocytes, NK cells, monocytes and platelets. |
| UniProt Number | Q01650 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
