CD18

Article No AFC-4846-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC-P, IHC-Fr, FA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone MEM-48
Clone Type monoclonal
Concentration 1 mg/ml
Conjugation Biotin
Description Mouse Monoclonal to CD18 / Integrin beta2 subunit
Recommended Dilution The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Supplier BioSite Flow
Immunogen Leukocytes of a patient suffering from a LGL-type leukemia.
Isotype IgG1
Keywords CD and Related Antigens (Human)
Notes CD18, integrin beta2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). In most cases, the response mediated by the integrin is a composite of the functions of its individual subunits. These integrins are essential for proper leukocyte migration, mediating intercellular contacts. Absence of CD18 leads to leukocyte adhesion deficiency-1; severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. CD18 is also a target of Mannheimia (Pasteurella) haemolytica leukotoxin and is sufficient to mediate leukotoxin-mediated cytolysis.
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Tris buffered saline (TBS) with 15 mM sodium azide, approx. pH 8.0
Technical Specifications The antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Product Page Updated 2018-07-27T09:12:01.609Z

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Species reactivity:

human human