CD79a

Article No AFC-4827-2
Product Type Antibodies Primary
Research Area Immunology
Application FC, IP, WB, IHC
Size 100 tests

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone HM47
Clone Type monoclonal
Conjugation APC
Description Mouse Monoclonal to CD79a
Recommended Dilution The purified antibody is conjugated with cross-linked Allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary.
Supplier BioSite Flow
Immunogen Synthetic peptide corresponding to C terminal amino acids 208-222 of human CD79a
Isotype IgG1
Keywords CD Antigens & MHC (Veterinary), CD and Related Antigens & MHC (Rodent), CD and Related Antigens (Human)
Notes CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Species Reactivity human, monkey, pig/porcine, mouse, rat, cow/bovine, dog/canine, horse/equine, guinea pig, rabbit, chicken
Storage Store in the dark at 2-8°C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.
Substrate / Buffer The reagent is provided in stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide.
Technical Specifications The mouse monoclonal antibody HM47 reacts with intracellular domain of CD79a (Ig alpha), a 40-45 kDa subunit of B cell antigen-specific receptor (BCR) and its early developmental forms.<br>
Product Page Updated 2019-05-20T06:41:23.567Z

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Species reactivity:

human, monkey, pig/porcine, mouse, rat, cow/bovine, dog/canine, horse/equine, guinea pig, rabbit, chicken human monkey mouse