Article No
AFC-A7H93K-0.1
Anti-Hu CD184 Purified
Anti-Hu CD184 Purified
Antibodies Primary
Specifications
| Application | FC, IHC, ICC |
| Article No | AFC-A7H93K-0.1 |
| Biosite Brand | Biosite Flow |
| Country Availability | all |
| Clone | 12G5 |
| Clone Type | monoclonal |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Description | Anti-Hu CD184 Purified |
| Supplier | Nordic Biosite |
| Entrez Gene ID | 7852 |
| Format | Purified |
| Immunogen | CP-MAC-infected Sup-T1 cells |
| Isotype | IgG2a k |
| Keywords | CD and Related Antigens (Human) |
| Notes | CD184, also known as CXCR4 or fusin, is a receptor for the C-X-C chemokine SDF-1. It is expressed mainly in hematopoietic cells, vascular endothelium, and neural tissue. CD184 is a G-protein coupled receptor containing extracellular N-terminal, seven transmembrane domains and intracellular C-terminal domain. It transduces signal by increasing the intracellular calcium level. CD184 plays an essential role in vascularization of the gastrointestinal tract, and is involved in cerebellar development and in hematopoiesis. It is also a coreceptor (with CD4) for HIV-1 X4 virus and a primary receptor for some HIV-2 isolates. |
| Alias Names | CXCR4, LAP3, LCR1, HM89, fusin, SDF1R |
| Previous Article No | AFC-4777E7, AFC-A7H93K-0.1 |
| Product Type | Antibodies Primary |
| Protocol | Flow cytometry: Recommended dilution: 2-4 μg/ml. |
| Purification | Purified by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Research area | Immunology |
| Size | 0.1 mg |
| Source / Host | mouse |
| Species Reactivity | human, monkey |
| Storage | Store at 2-8°C. Do not freeze. |
| Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
| Technical Specifications | The mouse monoclonal antibody 12G5 recognizes an extracellular epitope of CD184, a 45 kDa G-protein-linked CXC chemokine receptor widely expressed on blood and tissue cells. |
| UniProt Number | P61073 |
| Product Page Updated | 2024-01-03T12:18:20.318Z |
