Article No
AFC-VUQ7VJ-0.1
Application | FC, IP, IHC, ICC |
Article No | AFC-VUQ7VJ-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | BNI3 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD152 Purified Low Endotoxin |
Supplier | Nordic Biosite |
Entrez Gene ID | 1493 |
Format | Purified Low Endotoxin |
Immunogen | Human CD152-IgG heavy chain fusion protein |
Isotype | IgG2a |
Keywords | CD and Related Antigens (Human) |
Notes | CD152 / CTLA-4 is a homodimeric transmembrane protein similar to CD28 and binding the same ligands, i.e. CD80 (B7.1) and CD86 (B7.2), but with higher affinity. Unlike CD28 with important costimulating functions, CD152 acts as an important inhibitory receptor essential for modulation of the immune system. CD152 / CTLA-4 becomes transiently expressed on activated T cells and its malfunction can cause autoimmune diseases, such as insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, or thyroid-associated orbitopathy. |
Alias Names | CTLA4, GSE, GRD4 |
Previous Article No | AFC-4687-2, AFC-VUQ7VJ-0.1 |
Product Type | Antibodies Primary |
Protocol | Flow cytometry: Recommended dilution: 1-4 µg/ml, Intracellular staining. |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research Area | Immunology |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4 |
Technical Specifications | The mouse monoclonal antibody BNI3 recognizes an extracellular domain of human CD152 / CTLA4, an approximately 45 kDa type I transmembrane protein serving as a negative regulator of T cell responses. |
UniProt Number | P16410 |
Product Page Updated | 2024-01-03T12:18:20.318Z |