CD120a

Article No AFC-4684-2
Product Type Antibodies Primary
Research Area Cell Signaling
Application FC, IP, IHC-P, IHC-Fr, FA
Size 0.1 mg

Specifications

Country Availability all
BioSite Brand BioSite Flow
Clone H398
Clone Type monoclonal
Concentration 1 mg/ml
Description Mouse Monoclonal to CD120a / TNF receptor 1
Supplier BioSite Flow
Immunogen Recombinant full length human CD120a
Isotype IgG2a
Keywords Cytokine Signaling (Human), CD and Related Antigens (Human)
Notes CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Purification Purified by protein-A affinity chromatography
Purity > 95% (by SDS-PAGE)
Species Reactivity human
Storage Store at 2-8°C. Do not freeze. Do not use after expiration date stamped on vial label.
Substrate / Buffer Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 μm filter sterilized. Endotoxin level is less than 0.01 EU/μg of the protein, as determined by the LAL test.
Technical Specifications The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
Product Page Updated 2018-07-27T09:12:01.609Z

Shipping info

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Species reactivity:

human human

Suggested protocols:

Immunoprecipitation

Immunoprecipitation