Article No
AFC-RR24ZV-0.1
Application | FC, IP, IHC |
Article No | AFC-RR24ZV-0.1 |
Biosite Brand | Biosite Flow |
Country Availability | all |
Clone | H398 |
Clone Type | monoclonal |
Concentration | 1 mg/ml |
Conjugation | Unconjugated |
Description | Anti-Hu CD120a Purified Low Endotoxin |
Supplier | Nordic Biosite |
Entrez Gene ID | 7132 |
Format | Purified Low Endotoxin |
Immunogen | Recombinant full length human CD120a |
Isotype | IgG2a |
Keywords | Cytokine Signaling (Human), CD and Related Antigens (Human) |
Notes | CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. |
Alias Names | TNF R1, TNFRSF1A, TNFR55, FPF, TBP1, p60 |
Previous Article No | AFC-4684-2, AFC-RR24ZV-0.1 |
Product Type | Antibodies Primary |
Protocol | Functional application: Blocking. Flow cytometry: Recommended dilution: 1-4 µg/ml |
Purification | Purified by protein-A affinity chromatography. |
Purity | > 95% (by SDS-PAGE) |
Research Area | Cell Signaling |
Size | 0.1 mg |
Source / Host | mouse |
Species Reactivity | human |
Storage | Store at 2-8°C. Do not freeze. |
Substrate / Buffer | Phosphate buffered saline (PBS), pH 7.4 |
Technical Specifications | The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta. |
UniProt Number | P19438 |
Product Page Updated | 2024-01-03T12:18:20.318Z |